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The Science Behind Biological Age Testing
Aging isn’t just about the number of years lived — it’s a biological process shaped by genetics and lifestyle, reflected in our epigenetics epigenetics: chemical modifications that influence how genes are turned on or off over time. Among these, DNA methylation is the most reliable and scientifically validated biomarker for measuring biological age, offering a better prediction of health risks and longevity than chronological age alone.
As we age, our DNA doesn’t change — but how it’s read does. DNA methylation involves the addition of chemical tags to specific parts of our DNA (called CpG sites), which can silence or activate genes. These patterns change in a consistent way with age and are closely linked to:
Two major trends are observed over time:
Together, these shifts contribute to aging and disease susceptibility — and can now bemeasured with high precision.
Modern epigenetic clocks use machine learning and large datasets to identify the most predictive methylation markers of aging. The result? A reliable estimate of biological age — and insights into whether a person is aging faster or slower than expected.
One of the most advanced models in use today is SYMPHONYAge, which not only provides a global biological age but also estimates aging at the level of specific systems, such as:
This allows for organ-specific insights and more personalized recommendations.
Epigenetic testing opens up a new layer of precision in preventive and personalized care. With biological age as a dynamic biomarker, clinicians can:
Accelerated epigenetic aging (also called EAA) has been linked to:
Unlike genetic predisposition, these risks reflect current biological processes — and can potentially be influenced by lifestyle, diet, supplements, or clinical interventions.
